The Molecular Biosensor and Imaging Center at Carnegie Mellon University is a collaboration of biologists, chemists, and imaging scientists developing fluorescence technologies for biomedical applications. MBIC is an innovative research environment that focuses on development and application of new scientific tools. MBIC technologies are used in drug discovery, neuroscience, biomedical imaging and cancer biology programs through a variety of partnerships. Technologies launched from MBIC include the Cyanine Dyes (Cy3, Cy5, Cy7), High Content Screening (Cellomics, Inc), Difference In-Gel Electrophoresis (DIGE), Qdots for In-vivo imaging, Fluorogen Activating Proteins, and DNA Nanotags.


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Ratiometric pH sensing revelas dendritic cell antigen transfer to acidic compartments. (Grover, et al. Angew. Chem. 2012) Pow, C.L., et al. (2008) J. Am. Chem. Soc. A Rainbow of Fluoromodules: A Promiscuous scFv Protein Binds to and Activates a Diverse Set of Fluorogenic Cyanine Dyes Multiple FAP clones can bind to distinct fluorogenic dyes without cross-reactivity, a set of orthogonal FAP-fluorogen pairs.

Demonstrated in various papers:
Szent-Gyorgyi, C.S. et al. (2008) Nature Biotech.
Zanotti, K.J. et al. (2011) Org. and Biomol. Chemistry.
Saurabh, S. et al. (2015) ACS Nano.

Latest Publications


  1. Xie, W, Jiao, B, Bai, Q, Ilin, VA, Sun, M, Burton, CE, Kolodieznyi, D, Calderon, MJ, Stolz, DB, Opresko, PL, St Croix, CM, Watkins, S, Van Houten, B, Bruchez, MP, Burton, EA. Chemoptogenetic ablation of neuronal mitochondria in vivo with spatiotemporal precision and controllable severity. Elife. 2020; 9 :. PubMed PMID:32180546.
  2. Canady, TD, Berlyoung, AS, Martinez, JA, Emanuelson, C, Telmer, CA, Bruchez, MP, Armitage, BA. Enhanced Hybridization Selectivity Using Structured GammaPNA Probes. Molecules. 2020; 25 (4):. PubMed PMID:32098111.
  3. Perkins, LA, Bruchez, MP. Fluorogen activating protein toolset for protein trafficking measurements. Traffic. 2020; 21 (4):333-348. PubMed PMID:32080949.
  4. Yalcintas, EP, Ackerman, DS, Korkmaz, E, Telmer, CA, Jarvik, JW, Campbell, PG, Bruchez, MP, Ozdoganlar, OB. Analysis of In Vitro Cytotoxicity of Carbohydrate-Based Materials Used for Dissolvable Microneedle Arrays. Pharm. Res. 2020; 37 (3):33. PubMed PMID:31942659.
  5. Singh, A, Marcoline, FV, Veshaguri, S, Kao, AW, Bruchez, M, Mindell, JA, Stamou, D, Grabe, M. Protons in small spaces: Discrete simulations of vesicle acidification. PLoS Comput. Biol. 2019; 15 (12):e1007539. PubMed PMID:31869334.
  6. Litvina, E, Adams, A, Barth, A, Bruchez, M, Carson, J, Chung, JE, Dupre, KB, Frank, LM, Gates, KM, Harris, KM, Joo, H, William Lichtman, J, Ramos, KM, Sejnowski, T, Trimmer, JS, White, S, Koroshetz, W. BRAIN Initiative: Cutting-Edge Tools and Resources for the Community. J. Neurosci. 2019; 39 (42):8275-8284. PubMed PMID:31619497.
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MBIC Scheduling


MBIC provides an on-line booking system for shared equipment and resources. To obtain a user account please contact either Haibing Teng, or Yehuda Creeger.


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Director

Professor Marcel Bruchez


Location

Carnegie Mellon University
4400 Fifth Avenue
Pittsburgh, PA 15213


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Phone: 412-268-3461
Fax: 412-268-6571