The Molecular Biosensor and Imaging Center at Carnegie Mellon University is a collaboration of biologists, chemists, and imaging scientists developing fluorescence technologies for biomedical applications. MBIC is an innovative research environment that focuses on development and application of new scientific tools. MBIC technologies are used in drug discovery, neuroscience, biomedical imaging and cancer biology programs through a variety of partnerships. Technologies launched from MBIC include the Cyanine Dyes (Cy3, Cy5, Cy7), High Content Screening (Cellomics, Inc), Difference In-Gel Electrophoresis (DIGE), Qdots for In-vivo imaging, Fluorogen Activating Proteins, and DNA Nanotags.
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- Fouquerel, E, Barnes, RP, Uttam, S, Watkins, SC, Bruchez, MP, Opresko, PL. Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis. Mol. Cell. 2019; :. PubMed PMID:31101499.
- Larsen, MB, Perez Verdaguer, M, Schmidt, BF, Bruchez, MP, Watkins, SC, Sorkin, A. Generation of endogenous pH-sensitive EGF receptor and its application in high-throughput screening for proteins involved in clathrin-mediated endocytosis. Elife. 2019; 8 :. PubMed PMID:31066673.
- Ackerman, DS, Altun, B, Kolodieznyi, D, Bruchez, MP, Tsourkas, A, Jarvik, JW. Antibody-Linked Fluorogen-Activating Proteins for Antigen Detection and Cell Ablation. Bioconjug. Chem. 2019; 30 (1):63-69. PubMed PMID:30543409.
- Tan, X, Bruchez, MP, Armitage, BA. Efficient Cytoplasmic Delivery of Antisense Probes Assisted by Cyclized-Peptide-Mediated Photoinduced Endosomal Escape. Chembiochem. 2019; 20 (5):727-733. PubMed PMID:30452106.
- Shelke, SA, Shao, Y, Laski, A, Koirala, D, Weissman, BP, Fuller, JR, Tan, X, Constantin, TP, Waggoner, AS, Bruchez, MP, Armitage, BA, Piccirilli, JA. Structural basis for activation of fluorogenic dyes by an RNA aptamer lacking a G-quadruplex motif. Nat Commun. 2018; 9 (1):4542. PubMed PMID:30382099.
- Stensrud, KF, Zanotti, KJ, Waggoner, AS, Armitage, BA. Spectral Properties of Fluorogenic Thiophene-derived Triarylmethane Dyes. Photochem. Photobiol. 2019; 95 (1):406-410. PubMed PMID:30339278.
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MBIC provides an on-line booking system for shared equipment and resources. To obtain a user account please contact either Haibing Teng, or Yehuda Creeger.
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Professor Marcel Bruchez
Carnegie Mellon University
4400 Fifth Avenue
Pittsburgh, PA 15213