The Molecular Biosensor and Imaging Center at Carnegie Mellon University is a collaboration of biologists, chemists, and imaging scientists developing fluorescence technologies for biomedical applications. MBIC is an innovative research environment that focuses on development and application of new scientific tools. MBIC technologies are used in drug discovery, neuroscience, biomedical imaging and cancer biology programs through a variety of partnerships. Technologies launched from MBIC include the Cyanine Dyes (Cy3, Cy5, Cy7), High Content Screening (Cellomics, Inc), Difference In-Gel Electrophoresis (DIGE), Qdots for In-vivo imaging, Fluorogen Activating Proteins, and DNA Nanotags.

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Latest Publications

  1. Litvina, E, Adams, A, Barth, A, Bruchez, M, Carson, J, Chung, JE, Dupre, KB, Frank, LM, Gates, KM, Harris, KM, Joo, H, William Lichtman, J, Ramos, KM, Sejnowski, T, Trimmer, JS, White, S, Koroshetz, W. BRAIN Initiative: Cutting-Edge Tools and Resources for the Community. J. Neurosci. 2019; 39 (42):8275-8284. PubMed PMID:31619497.
  2. Bruchez, M. Rev Med Suisse. 2019; 15 (665):1780. PubMed PMID:31580026.
  3. Kuljis, DA, Park, E, Telmer, CA, Lee, J, Ackerman, DS, Bruchez, MP, Barth, AL. Fluorescence-based quantitative synapse analysis for cell-type specific connectomics. eNeuro. 2019; :. PubMed PMID:31548370.
  4. Whinn, KS, Kaur, G, Lewis, JS, Schauer, GD, Mueller, SH, Jergic, S, Maynard, H, Gan, ZY, Naganbabu, M, Bruchez, MP, O'Donnell, ME, Dixon, NE, van Oijen, AM, Ghodke, H. Nuclease dead Cas9 is a programmable roadblock for DNA replication. Sci Rep. 2019; 9 (1):13292. PubMed PMID:31527759.
  5. Qian, W, Kumar, N, Roginskaya, V, Fouquerel, E, Opresko, PL, Shiva, S, Watkins, SC, Kolodieznyi, D, Bruchez, MP, Van Houten, B. Chemoptogenetic damage to mitochondria causes rapid telomere dysfunction. Proc. Natl. Acad. Sci. U.S.A. 2019; 116 (37):18435-18444. PubMed PMID:31451640.
  6. Armitage, BA. Targeting G-Quadruplexes with PNA Oligomers. Methods Mol. Biol. 2019; 2035 :333-345. PubMed PMID:31444760.
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MBIC Scheduling

MBIC provides an on-line booking system for shared equipment and resources. To obtain a user account please contact either Haibing Teng, or Yehuda Creeger.

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Contact us


Professor Marcel Bruchez


Carnegie Mellon University
4400 Fifth Avenue
Pittsburgh, PA 15213


Phone: 412-268-3461
Fax: 412-268-6571