The Molecular Biosensor and Imaging Center at Carnegie Mellon University is a collaboration of biologists, chemists, and imaging scientists developing fluorescence technologies for biomedical applications. MBIC is an innovative research environment that focuses on development and application of new scientific tools. MBIC technologies are used in drug discovery, neuroscience, biomedical imaging and cancer biology programs through a variety of partnerships. Technologies launched from MBIC include the Cyanine Dyes (Cy3, Cy5, Cy7), High Content Screening (Cellomics, Inc), Difference In-Gel Electrophoresis (DIGE), Qdots for In-vivo imaging, Fluorogen Activating Proteins, and DNA Nanotags.

Learn More About MBIC
 

Slide Slide Slide Ratiometric pH sensing revelas dendritic cell antigen transfer to acidic compartments. (Grover, et al. Angew. Chem. 2012) Slide Slide Pow, C.L., et al. (2008) J. Am. Chem. Soc. A Rainbow of Fluoromodules: A Promiscuous scFv Protein Binds to and Activates a Diverse Set of Fluorogenic Cyanine Dyes Slide Multiple FAP clones can bind to distinct fluorogenic dyes without cross-reactivity, a set of orthogonal FAP-fluorogen pairs.

Demonstrated in various papers:
Szent-Gyorgyi, C.S. et al. (2008) Nature Biotech.
Zanotti, K.J. et al. (2011) Org. and Biomol. Chemistry.
Saurabh, S. et al. (2015) ACS Nano.

Latest Publications

  1. Zhong, Z, Ning, J, Boggs, EA, Jang, S, Wallace, C, Telmer, C, Bruchez, MP, Ahn, J, Engelman, AN, Zhang, P, Watkins, SC, Ambrose, Z. Cytoplasmic CPSF6 Regulates HIV-1 Capsid Trafficking and Infection in a Cyclophilin A-Dependent Manner. mBio. 2021; 12 (2):. PubMed PMID:33758083.
  2. Liang, P, Ballou, B, Lv, X, Si, W, Bruchez, MP, Huang, W, Dong, X. Monotherapy and Combination Therapy Using Anti-Angiogenic Nanoagents to Fight Cancer. Adv Mater. 2021; :e2005155. PubMed PMID:33684242.
  3. Missinato, MA, Zuppo, DA, Watkins, SC, Bruchez, MP, Tsang, M. Zebrafish heart regenerates after chemoptogenetic cardiomyocyte depletion. Dev Dyn. 2021; :. PubMed PMID:33501711.
  4. Liang, P, Kolodieznyi, D, Creeger, Y, Ballou, B, Bruchez, MP. Subcellular Singlet Oxygen and Cell Death: Location Matters. Front Chem. 2020; 8 :592941. PubMed PMID:33282833.
  5. Berlyoung, AS, Armitage, BA. Assembly and Characterization of RNA/DNA Hetero-G-Quadruplexes. Biochemistry. 2020; 59 (42):4072-4080. PubMed PMID:33048532.
  6. Carpenter, MA, Wang, Y, Telmer, CA, Schmidt, BF, Yang, Z, Bruchez, MP. Protein Proximity Observed Using Fluorogen Activating Protein and Dye Activated by Proximal Anchoring (FAP-DAPA) System. ACS Chem Biol. 2020; 15 (9):2433-2443. PubMed PMID:32786268.
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News & Events

MBIC investigators in the news and MBIC related seminar and event announcements.

All News

MBIC team develops optogenetic photosensitizer

January 28, 2016

MBIC/Duke Drug Screening

January 21, 2016

MBIC Scheduling

MBIC provides an on-line booking system for shared equipment and resources. To obtain a user account please contact either Haibing Teng, or Yehuda Creeger.

Visit Scheduling Page

Instrument Status

Zeiss LSM 510 Meta Confocor3
Zeiss LSM 880 Meta FCS
Andor Revolution XD Spinning Disk
Illumina MiSEQ Desktop Sequencer
Tecan Safire 2
Tecan M1000 (MI749)
FACS Vantage Sorter
Accuri/Intellicyt HTFC
IVIS Spectrum/CT Imager

Contact us

Director

Professor Marcel Bruchez

Location

Carnegie Mellon University
4400 Fifth Avenue
Pittsburgh, PA 15213

Call

Phone: 412-268-3461
Fax: 412-268-6571